Histogenesis and progression in ultraviolet light-induced tumors in hairless mice

Journal Article · Tue Dec 01 04:00:00 EST 1981 · JNCI, J. Natl. Cancer Inst.; (United States)

OSTI ID:5509542

Kligman, L H; Kligman, A M

Tumor histogenesis and progression were studied in UV-irradiated albino (Skh:hairless-1) and lightly pigmented (Skh:hairless-2) hairless mice. A strongly carcinogenic dose of UV light was used, producing 100% tumor incidence by 35 weeks. The light source emitted mainly UV radiation in the range of 280-320 nm and the less energetic UV radiation up to 400 nm. The resulting epidermal changes and neoplasms resembled those seen in the actinically damaged skin of humans. Microscopic lesions included benign hyperplasia, actinic keratoses, and squamous cell carcinoma in situ and with microinvasion. Clinical tumors were epithelial papillomas, fibropapillomas, keratoacanthomas, cystic keratomas, benign pigmented macules, cutaneous hornlike growth, exophytic and endophytic squamous cell carcinomas of several cytologic types, and fibrosarcomas. Even with this high dose of UV radiation, not all of the small tumors progressed to cancer. Many regressed, including some keratoacanthomas, whereas others remained small and benign for the lifetime of the mouse.

• Research Organization: Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia
• OSTI ID: 5509542
• Journal Information: JNCI, J. Natl. Cancer Inst.; (United States), Journal Name: JNCI, J. Natl. Cancer Inst.; (United States) Vol. 67:6; ISSN JJIND
• Country of Publication: United States
• Language: English

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