Radiation synovectomy stimulates glycosaminoglycan synthesis by normal articular cartilage

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · J. Lab. Clin. Med.; (United States)

OSTI ID:5696582

Myers, S L; Slowman, S D; Brandt, K D

Radiation synovectomy has been considered a therapeutic alternative to surgical synovectomy. Whether intraarticular irradiation affects the composition or biochemistry, and therefore the biomechanical properties, of normal articular cartilage has not been established. In the present study, yttrium 90 silicate was injected into one knee of nine normal adult dogs, and three other dogs received nonradioactive yttrium silicate. When the animals were killed 4 to 13 weeks after the injection, synovium from the irradiated knees showed areas of necrosis and fibrosis. Up to 29% less hyaluronate was synthesized in vitro by the synovial intima from irradiated knees than by the intima from the contralateral knees (mean difference 18%). Morphologic abnormalities were not observed in articular cartilage from either the irradiated or control knees, nor did the water content or concentrations of uronic acid or DNA in cartilage from the irradiated knees differ from that in cartilage from the contralateral knees. However, net /sup 35/SO/sub 4/-labeled glycosaminoglycan synthesis in organ cultures of cartilage from irradiated knees was increased (mean difference 21%, p = 0.03) in comparison with that in cultures of contralateral knee cartilage.

• Research Organization: Indiana Univ. Multipurpose Arthritis Center, Indianapolis (USA)
• OSTI ID: 5696582
• Journal Information: J. Lab. Clin. Med.; (United States), Journal Name: J. Lab. Clin. Med.; (United States) Vol. 114:1; ISSN JLCMA
• Country of Publication: United States
• Language: English

Related Subjects

550901 -- Pathology-- Tracer Techniques
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
BODY AREAS
BONE JOINTS
CARBOHYDRATES
CARTILAGE
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DOGS
EVEN-ODD NUCLEI
FIBROSIS
GLYCOPROTEINS
HOURS LIVING RADIOISOTOPES
HYALURONIC ACID
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEGS
LIGHT NUCLEI
LIMBS
MAMMALS
MUCOPOLYSACCHARIDES
NECROSIS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
POLYSACCHARIDES
PROTEINS
RADIATION EFFECTS
RADIOISOTOPES
SACCHARIDES
SKELETON
SULFUR 35
SULFUR ISOTOPES
SYNTHESIS
TISSUES
TRACER TECHNIQUES
VERTEBRATES
YTTRIUM 90
YTTRIUM ISOTOPES