Survival enhancement and hemopoietic regeneration following radiation exposure: therapeutic approach using glucan and granulocyte colony-stimulating factor

Technical Report · Mon Jan 01 00:00:00 EST 1990

OSTI ID:5681219

Patchen, M L; MacVittie, T J; Solberg, B D; Souza, L M

C3H/HeN female mice were exposed to whole-body cobalt-60 radiation and administered soluble glucan (5 mg i.v. at 1 h following exposure), recombinant human granulocyte colony-stimulating factor or both agents. Treatments were evaluated for their ability to enhance hemopoietic regeneration, and to increase survival after radiation-induced myelosuppression. Both glucan and G-CSF enhanced hemopoietic regeneration alone; however, greater effects were observed in mice receiving both agents. For example, on day 17 following a sublethal 6.5-Gy radiation exposure, mice treated with saline, G-CSF, glucan, or both agents, respectively, exhibited 36%, 65%, 50%, and 78% of normal bone marrow cellularity, and 84%, 175%, 152%, and 212% of normal splenic cellularity.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
• OSTI ID: 5681219
• Report Number(s): AD-A-230978/9/XAB; AFRRI-SR-90-36
• Resource Relation: Other Information: Pub. in Experimental Hematology, v18 p1042-1048 1990
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GROWTH FACTORS
RADIOSENSITIVITY EFFECTS
HEMATOPOIETIC SYSTEM
BIOLOGICAL REGENERATION
PROTEINS
BIOLOGICAL RADIATION EFFECTS
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INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MITOGENS
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ODD-ODD NUCLEI
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560152* - Radiation Effects on Animals- Animals