Dopamine receptors in pituitary adenomas: PET visualization with 11C-N-methylspiperone
Two patients with pituitary tumors were examined with positron emission tomography (PET) after intravenous administration of 11C-N-methylspiperone. In repeat studies the patients were given 1 mg of intravenous haloperidol prior to the administration of the radioligand to block the dopamine receptors. High uptakes of the radiolabeled ligand were seen in one of the tumors. With haloperidol pretreatment the uptake was lower, probably mainly showing the remaining unspecific binding. The most marked uptake and the largest effect of haloperidol pretreatment was seen in a patient with a hormonally active prolactinoma. Dopamine receptor binding in pituitary tumors can be demonstrated in vivo with PET, and quantification of this binding is possible using a compartmental model. This technique may be useful in improving our understanding of the variable response to medical treatment of prolactinomas with dopamine agonists as well as in the prediction of the effect of such treatment.
- Research Organization:
- Univ. Hospital, Uppsala, Sweden
- OSTI ID:
- 5680288
- Journal Information:
- J. Comput. Assist. Tomogr.; (United States), Journal Name: J. Comput. Assist. Tomogr.; (United States) Vol. 2; ISSN JCATD
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOMAS
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON 11
CARBON ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOPAMINE
DRUGS
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEMBRANE PROTEINS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NEUROREGULATORS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PHENOLS
PITUITARY GLAND
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
PROTEINS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RECEPTORS
SYMPATHOMIMETICS
TOMOGRAPHY