Effects of dietary zinc, manganese, and copper on tissue accumulation of cadmium by Japanese quail

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-172-41522· OSTI ID:5680176

Jacobs, R M ^[1]; Jones, A O; Fox, M R; Lener, J

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1. Food and Drug Administration, Washington, DC

The beneficial effects of a combined dietary supplement of Zn, Cu, and Mn in decreasing Cd absorption was previously reported. The purpose of this study was to investigate the individual and combined effects of these three elements. In the first two experiments, day-old Japanese quail were fed basal diets containing either requirement amounts of Zn (30 ppm) and Mn (12 ppm) and slightly above requirement levels of Cu (5 ppm). From Day 7 birds were fed either the basal diet or diets containing combinations at twice these concentrations; a 2 x 2 x 2 factorial design was used. /sup 109/Cd content and Cd concentration of these diets were 100 ..mu..Ci and 145 ..mu..g/kg, respectively. In the third experiment, day-old birds were fed either the basal diet or a basal diet containing /sup 109/Cd and single additional supplements of either Zn, Cu, or Mn. All birds were killed at 14 days of age. The Cd concentration was determined for the duodenum, jejunum-ileum, liver, and kidney. When the experimental diets were fed for 7 days, only Zn had a protective effect against Cd. Whereas none of the elements reduced the Cd concentration of the duodenum, Zn reduced the Cd in the jejunum-ileum, liver, and kidney by approximately 66, 21, and 11%, respectively. Cu and Mn caused occasional increases of Cd in some tissues. Feeding the experimental diets for 2 weeks resulted in similar responses. Zn nutrition appears to play an important role in protecting against dietary Cd absorption.

• OSTI ID: 5680176
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 172:1; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTROSCOPY
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIRDS
BODY
CADMIUM
CADMIUM 109
CADMIUM ISOTOPES
COPPER
COUNTING TECHNIQUES
DIET
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
MANGANESE
METALS
NUCLEI
NUTRITION
ORGANS
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
SCINTILLATION COUNTING
SMALL INTESTINE
SPECTROSCOPY
TABLES
TRANSITION ELEMENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
ZINC