Bioavailability of cadmium from soy isolate
Studies with /sup 109/Cd showed that more Cd was taken up by duodenum (D) and jejunum-ileum (J-I) of Japanese Quail (JQ) with soy isolate (SI) than with casein gelatin (CG) diet. The purpose of this study was to compare the bioavailability of endogenous Cd from SI with CdCl/sub 2/ added to a CG diet. Day-old JQ were fed either SI or CG diet containing 121 ppb of Cd. Beginning at 7 d of age, /sup 109/CdCl/sub 2/ was incorporated into both diets at 100 uci/kg and a group of birds from each diet was killed on 8, 9, 11, 14 and 21 d. Growth was normal with both diets and food intake was similar. Cd concentration (determined by ICAP and AAS furnace) was significantly higher with CG than with SI on all days in D and up to 11 d of age in J-I. Although much less Cd accumulated in liver and kidneys than in D and J-I, the levels were also higher with CG. Total Cd uptake by liver and kidneys increased gradually with CG whereas there was little increase with SI. Specific activity of Cd in D and J-I with CG remained the same throughout the experiment, but increased significantly with SI up to 11 d of age. The specific activity of Cd in liver and kidneys from both CG and SI increased with time but the rate was greater with SI. The patterns of specific activity indicate differences among tissues and between CG and SI for time required to reach equilibrium between /sup 109/Cd and non-radioactive Cd. These data also show that endogenous Cd in SI is less bioavailable than CdCl/sub 2/ added to CG diet.
- Research Organization:
- FDA, Washington, DC
- OSTI ID:
- 5435489
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL AVAILABILITY
BIRDS
BODY
CADMIUM
CADMIUM 109
CADMIUM ISOTOPES
DIET
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTESTINES
ISOTOPES
KIDNEYS
LIVER
METALS
NUCLEI
ORGANS
RADIOISOTOPES
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES