Distribution and accumulation of (2,3-/sup 14/C)acrylonitrile in rat after single injection

Journal Article · Fri Oct 01 04:00:00 EDT 1982 · Ecotoxicol. Environ. Saf.; (United States)

DOI:https://doi.org/10.1016/0147-6513(82)90030-6· OSTI ID:5679986

Sato, M; Hirasawa, F; Ogata, M; Takizawa, Y; Kojima, H; Yoshida, T

The distribution and accumulation of acrylonitrile after the single i.p. injection of (2,3-/sup 14/C)acrylonitrile were examined by whole-body autoradiography and by the determination of /sup 14/C radioactivities in several tissues and subcellular fractions after a whole-body perfusion. /sup 14/C Radioactivity was seen strongly in blood, particularly in red blood cells, and in several tissues including lung, liver, and kidney. Longer retention of radioactivity in brain and muscle was observed. At the subcellular level a relatively high specific radioactivity was seen in cytosol fractions of the brain, liver, and kidney.

• Research Organization: Department of Public Health, Akita University, School of Medicine, Japan
• OSTI ID: 5679986
• Journal Information: Ecotoxicol. Environ. Saf.; (United States), Journal Name: Ecotoxicol. Environ. Saf.; (United States) Vol. 6:5; ISSN EESAD
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRYLONITRILE
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
GLANDS
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MATERIALS
MUSCLES
NERVOUS SYSTEM
NITRILES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
WHOLE-BODY COUNTING