Subchronic treatment with sodium 2,3-dimercaptopropane-1-sulfonate in methylmercury poisoning
Journal Article
·
· Bull. Environ. Contam. Toxicol.; (United States)
The study describes the effects of subchronic 2,3-dimercaptopropane-l-sulfonate (DMPS) treatment for four weeks on the elimination of /sup 203/Hg-methylmercury injection i.p. in male Sprague-Dawley rats. Radioactivity in urine, feces and whole body as well as in tissues was measured in a whole body counter. Data show that during 28 days control rats eliminated 48.2 + or - 10.9 percent of the administered dose, DMPS treated rats 82.4 + or - 18.2 percent. Organ distribution showed an enrichment of /sup 203/Hg in kidneys, blood and skin as compared to the whole body in treated and control rats. Mercury concentrations were lowered to about 15-30 percent of control values in all tissues with the exception of skin (70 percent). (JMT)
- Research Organization:
- Universitat Munchen, Federal Republic of Germany
- OSTI ID:
- 5621531
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 29:4; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHELATING AGENTS
CLEARANCE
DAYS LIVING RADIOISOTOPES
EVALUATION
EVEN-ODD NUCLEI
EXCRETION
GAMMA SPECTROSCOPY
HEAVY NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MERCURY 203
MERCURY COMPOUNDS
MERCURY ISOTOPES
METHYLMERCURY
NUCLEI
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
SPECTROSCOPY
THERAPY
TOXICITY
TRACER TECHNIQUES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHELATING AGENTS
CLEARANCE
DAYS LIVING RADIOISOTOPES
EVALUATION
EVEN-ODD NUCLEI
EXCRETION
GAMMA SPECTROSCOPY
HEAVY NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MERCURY 203
MERCURY COMPOUNDS
MERCURY ISOTOPES
METHYLMERCURY
NUCLEI
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
SPECTROSCOPY
THERAPY
TOXICITY
TRACER TECHNIQUES