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Estimation of mercury burdens in rats by chelation with dimercaptopropane sulfonate

Journal Article · · J. Pharmacol. Exp. Ther.; (United States)
OSTI ID:6991766
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The chelation of mercury by 2,3-dimercaptopropane-1-sulfonate (DMPS) and its usefulness in the estimation of mercury burdens was investigated by exposing male, Sprague-Dawley rats to /sup 203/HgCl/sub 2/ (0.1-2 mg of Hg per kg i.p.) or /sup 203/Hg vapor (0.5-2.0 mg of Hg per m3). DMPS (0.2-2.0 mmol/kg) was injected i.p. at times ranging from 1 to 38 days after exposure to the mercurial. Urine and feces were collected for 24 hr before and after DMPS treatment. Whole body mercury levels, tissue levels and excretion of mercury were measured by radioactivity counting. After DMPS treatment there was a significant decrease of whole body mercury levels and an increase in urinary excretion. The increase in urinary excretion was directly proportional to the whole body burden of mercury at the time of dosing with DMPS in animals dosed with HgCl/sub 2/ and exposed to mercury vapor. Furthermore, the increase in urinary excretion induced by DMPS was almost equal to the amount of mercury lost from the kidneys.
Research Organization:
Univ. of Western Ontario, London (Canada)
OSTI ID:
6991766
Journal Information:
J. Pharmacol. Exp. Ther.; (United States), Journal Name: J. Pharmacol. Exp. Ther.; (United States) Vol. 245:2; ISSN JPETA
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY BURDEN
CHELATING AGENTS
DAYS LIVING RADIOISOTOPES
DITHIOLS
ELEMENTS
EVEN-ODD NUCLEI
HEAVY NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MERCURY
MERCURY 203
MERCURY ISOTOPES
METABOLISM
METALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOISOTOPES
RATS
REAGENTS
RODENTS
SULFONIC ACIDS
THIOLS
TRACER TECHNIQUES
UNITHIOL
VERTEBRATES