Assessment of the radiosensitivity of ataxia-telangiectasia heterozygotes
Journal Article
·
· KROC Found. Ser.; (United States)
OSTI ID:5676238
Heterozygotes of ataxia-telangiectasia (AT) can, in certain parts of the world, represent a significant proportion of the population. Epidemiological studies suggest that they are more cancer prone than normal individuals. Fibroblasts of five AT heterozygotes are significantly more sensitive to gamma irradiation (mean D0 = 1.18 Gy) than five normals (mean D0 = 1.49 Gy) although some overlap in response is observed. Experiments designed to maximize differences in survival by allowing a period for the repair of potentially lethal damage (PLD) showed that only one out of five AT heterozygotes was defective in the repair of PLD. This technique does not, therefore, permit an improved discrimination of AT heterozygotes. Two AT heterozygotes were tested for their ability to repair lesions that give rise to micronuclei. Both, like the homozygote, were seen to be defective in this capacity. Defects in the repair of chromosome damage may permit a cellular discrimination of the heterozygotes.
- OSTI ID:
- 5676238
- Journal Information:
- KROC Found. Ser.; (United States), Journal Name: KROC Found. Ser.; (United States); ISSN KFSED
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900 -- Pathology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARCINOMAS
CONGENITAL DISEASES
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPAIR
ELECTROMAGNETIC RADIATION
EPIDEMIOLOGY
FIBROBLASTS
GAMMA RADIATION
IONIZING RADIATIONS
NEOPLASMS
PATIENTS
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SOMATIC CELLS
VASCULAR DISEASES
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARCINOMAS
CONGENITAL DISEASES
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPAIR
ELECTROMAGNETIC RADIATION
EPIDEMIOLOGY
FIBROBLASTS
GAMMA RADIATION
IONIZING RADIATIONS
NEOPLASMS
PATIENTS
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SOMATIC CELLS
VASCULAR DISEASES