Synthesis of a precursor for the preparation of 9 alpha,11 alpha-tritiated 5 alpha-androstane-3 alpha,17 beta-diol 17-glucuronide
Journal Article
·
· Steroids; (United States)
Starting from 11 beta-hydroxytestosterone, the synthesis of a strategic precursor, C-9 (11) unsaturated 5 alpha-androstane-3 alpha, 17 beta-diol 17-glucuronide (9a), for the preparation of 9 alpha,11 alpha-tritiated 5 alpha-androstane-3 alpha, 17 beta-diol 17-glucuronide has been achieved. The authors optimized the reaction conditions for catalytic reduction employing hydrogen and subsequent base hydrolysis followed by purification on Amberlite XAD-2 resin to obtain the saturated 5 alpha-androstane-3 alpha, 17 beta-diol 17-glucuronide.
- Research Organization:
- Southwest Foundation for Biomedical Research, San Antonio, TX
- OSTI ID:
- 5675485
- Journal Information:
- Steroids; (United States), Journal Name: Steroids; (United States) Vol. 43:3; ISSN STEDA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
ALDEHYDES
ANDROGENS
ANDROSTANES
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
DECOMPOSITION
ELEMENTS
GLUCURONIC ACID
HORMONES
HYDROGEN
HYDROLYSIS
HYDROXY ACIDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
LYSIS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRECURSOR
PURIFICATION
SOLVOLYSIS
STEROID HORMONES
STEROIDS
SYNTHESIS
TESTOSTERONE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
ALDEHYDES
ANDROGENS
ANDROSTANES
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
DECOMPOSITION
ELEMENTS
GLUCURONIC ACID
HORMONES
HYDROGEN
HYDROLYSIS
HYDROXY ACIDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
LYSIS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRECURSOR
PURIFICATION
SOLVOLYSIS
STEROID HORMONES
STEROIDS
SYNTHESIS
TESTOSTERONE
TRACER TECHNIQUES
TRITIUM COMPOUNDS