Ceruletide intravenous dose-response study by a simplified scintigraphic technique

Conference · Mon Apr 01 00:00:00 EST 1985 · AJR, Am. J. Roentgenol.; (United States)

OSTI ID:5665757

Krishnamurthy, G T; Turner, F E; Mangham, D; Bobba, V V.R.; White, S A; Langrell, K

The intravenous dose response of a ceruletide diethylamine (ceruletide) was established by a simplified scintigraphic technique where multiple graded doses were given sequentially on a single occasion. The gallbladder volume was presented nongeometrically by /sup 99m/Tc-IDA counts. The mean latent period, ejection period, and ejection rate were similar for all four groups of subjects given 1-20 ng/kg of ceruletide. The ejection fractions were similar to the values when the identical dose of ceruletide was administered sequentially either before or after another dose. A dose of 5 ng/kg produced the most physiologic type of emptying. Intravenous doses of 10 ng/kg and larger caused adverse reactions in 42% of the total doses in the form of abdominal pain, nausea, systolic and diastolic hypotension, or bradycardia. It is concluded that the dose response of a cholecystokininlike agent (ceruletide) can be established reliably by a scintigraphic technique where multiple graded doses are given on a single occasion.

• Research Organization: Veterans Administration Medical Center, Portland, OR
• OSTI ID: 5665757
• Report Number(s): CONF-8504141-; TRN: 85-013973
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Vol. 144:4; Conference: AARRS meeting, Boston, MA, USA, 21 Apr 1985
• Country of Publication: United States
• Language: English

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