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Safety of exogenous (CCK-8) and endogenous (fatty meal) cholecystokinin (CCK) induced gallbladder (GB) dynamics in patients with cholelithiasis

Conference · · J. Nucl. Med.; (United States)
OSTI ID:6859322
;
The quantitation of biliary dynamics in patients requires induction of GB contraction and emptying the CCK. However, it is not clear how safe it is to induce GB emptying in a patient with known gallstones. This study was undertaken to document the safety of induction of GB emptying in 50 patients with gallstones and the results are compared with 55 normal subjects. After 4-6 hours of fast, each subject was given 3-5 mCi of Tc-99m-IDA. Sixty minutes later, the subject was positioned under a gamma camera and the data were acquired at 1 frame/min. for 30 min. (CCK-8) or 60 minutes (fatty meal). Saline placebo was given at 5 minutes and CCK-8 or fatty meal at 10 minutes. Onset of symptoms was recorded and correlated with GB ejection period. GB ejection fraction (EF) was calculated for 3 doses (5, 10 and 40 ng/kg) of CCK-8 and fatty meal (8 oz/70 kg). Compared to normals, GB emptying in general was lower in patients with cholelithiasis for all 3 doses of CCK-8 and fatty meal. Five patients (10%) with choleithiasis experienced a mild to moderate degree of nausea and intermittent abdominal pain during GB ejection and the symptoms were similar to their previous experience during an attack of cholecystitis. All symptoms abated within 10 minutes without therapy. No incidence of impaction of GB stone in the common bile duct was seen. It is concluded that the GB emptying required for quantitative biliary dynamics can be induced safely with either exogenous or endongenous CCK in patients with known cholelithiasis.
Research Organization:
VA Medical Center, Portland, OR
OSTI ID:
6859322
Report Number(s):
CONF-840619-
Conference Information:
Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
Country of Publication:
United States
Language:
English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
CALCULI
CAMERAS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DATA ACQUISITION
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
GAMMA CAMERAS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SAFETY
SCINTISCANNING
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
YEARS LIVING RADIOISOTOPES