Measurement of gallbladder emptying sequentially using a single dose of /sup 99m/Tc-labeled hepatobiliary agent

Journal Article · Fri Oct 01 04:00:00 EDT 1982 · Gastroenterology; (United States)

OSTI ID:6856549

Krishnamurthy, G T; Bobba, V R; Kingston, E; Turner, F

The gallbladder emptying response to a single large (20 ng/kg) and four equally divided sequential small (5 ng/kg each) doses of octapeptide of cholecystokinin at 20-min intervals was measured in a paired study in six normal subjects noninvasively and quantitatively by a nongeometric method using a gamma camera, computer, and /sup 99m/Tc labeled hepatobiliary agent. The gallbladder mean (+/- SD) ejection fraction after a single large dose (20 ng/kg) of octapeptide of cholecystokinin was 34 +/- 24% and after four sequential small (5 ng/kg each) doses was 42 +/- 14%, 45 +/- 28%, 37 +/- 22%, and 32 +/- 27%, respectively (p greater than 0.05). The results of this study indicate that the first part of the 5 ng/kg sequential octapeptide of cholecystokinin dose is as effective as the single 20-ng/kg dose. The gallbladder emptying requires continued presence of high levels of octapeptide of cholecystokinin in the serum closer to levels that initiate contraction and in the absence of which the gallbladder ceases to empty further despite the fact it has inherent capacity to do so. Each of four equal octapeptide of cholecystokinin doses given sequentially elicits, on the average, an equal degree of emptying response. The method has potential for application in the study of the pharmacological effects of drugs on the biliary dynamics using a single dose of /sup 99/mTc-labeled hepatobiliary radiopharmaceutical.

• Research Organization: Nuclear Medicine and Research Services, Veterans Administration Medical Center, Portland, Oregon
• OSTI ID: 6856549
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 83:4; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DRUGS
DYNAMIC FUNCTION STUDIES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
PATHOLOGY
PHYSIOLOGY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
USES
YEARS LIVING RADIOISOTOPES