Quantitation of uveoscleral outflow in normotensive and glaucomatous Beagles by /sup 3/H-labeled dextran

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Am. J. Vet. Res.; (United States)

OSTI ID:5655243

Barrie, K P; Gum, G G; Samuelson, D A; Gelatt, K N

In uveoscleral outflow, aqueous humor leaves the anterior chamber and passes caudally through the trabecular meshwork and the sclerociliary cleft to enter the supraciliary and suprachoroidal spaces. The fluid is then absorbed by choroidal and scleral circulations. Using /sup 3/H-labeled dextran, uveoscleral outflow was quantitated in normotensive and glaucomatous Beagles under general anesthesia. The intrascleral plexus was isolated and /sup 3/H-labeled dextran was injected into the anterior chamber. Intrascleral plexus contents were sampled every 5 minutes over a 30- to 60-minute period. The eyes were enucleated, sectioned, and prepared for scintillation counting. Uveoscleral outflow accounted for 15% and 3% of the total aqueous humor outflow in the normotensive dogs and in the advanced glaucomatous dogs, respectively. In the advanced glaucomatous Beagle, conventional and uveoscleral outflow pathways were reduced and contributed to the etiopathogenesis of glaucoma.

• Research Organization: Univ. of Florida, Gainesville
• OSTI ID: 5655243
• Journal Information: Am. J. Vet. Res.; (United States), Vol. 46:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
EYES
SCINTISCANNING
SENSE ORGANS DISEASES
PATHOGENESIS
BODY FLUIDS
DEXTRAN
DOGS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD SUBSTITUTES
BODY
BODY AREAS
CARBOHYDRATES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
FACE
HEAD
HEMATOLOGIC AGENTS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPE SCANNING
SACCHARIDES
SENSE ORGANS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics