Quantitation of uveoscleral outflow in normotensive and glaucomatous Beagles by /sup 3/H-labeled dextran
In uveoscleral outflow, aqueous humor leaves the anterior chamber and passes caudally through the trabecular meshwork and the sclerociliary cleft to enter the supraciliary and suprachoroidal spaces. The fluid is then absorbed by choroidal and scleral circulations. Using /sup 3/H-labeled dextran, uveoscleral outflow was quantitated in normotensive and glaucomatous Beagles under general anesthesia. The intrascleral plexus was isolated and /sup 3/H-labeled dextran was injected into the anterior chamber. Intrascleral plexus contents were sampled every 5 minutes over a 30- to 60-minute period. The eyes were enucleated, sectioned, and prepared for scintillation counting. Uveoscleral outflow accounted for 15% and 3% of the total aqueous humor outflow in the normotensive dogs and in the advanced glaucomatous dogs, respectively. In the advanced glaucomatous Beagle, conventional and uveoscleral outflow pathways were reduced and contributed to the etiopathogenesis of glaucoma.
- Research Organization:
- Univ. of Florida, Gainesville
- OSTI ID:
- 5655243
- Journal Information:
- Am. J. Vet. Res.; (United States), Journal Name: Am. J. Vet. Res.; (United States) Vol. 46:1; ISSN AJVRA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pattern-evoked potentials and optic nerve fiber loss in monocular laser-induced glaucoma
Ultrastructural and pharmacologic studies on laser-induced glaucoma in primates and rabbits
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BIOLOGICAL MATERIALS
BLOOD SUBSTITUTES
BODY
BODY AREAS
BODY FLUIDS
CARBOHYDRATES
COUNTING TECHNIQUES
DEXTRAN
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DRUGS
EYES
FACE
HEAD
HEMATOLOGIC AGENTS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
POLYSACCHARIDES
RADIOISOTOPE SCANNING
SACCHARIDES
SCINTISCANNING
SENSE ORGANS
SENSE ORGANS DISEASES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES