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Stimulation of cell division by argon and Nd:YAG laser trabeculoplasty in cynomolgus monkeys

Journal Article · · Investigative Ophthalmology and Visual Science; (USA)
OSTI ID:6991368
; ; ; ;  [1]
  1. Univ. of Missouri, Columbia (USA)
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Although laser treatment of the trabecular meshwork is the most common form of surgery for glaucoma, the tissue response to this therapy is still incompletely understood. We applied argon or Nd:YAG laser to the trabecular meshwork of six monkeys. Cell division was identified by injecting tritiated thymidine into the anterior chamber 24 hr after laser application. Autoradiography of tissue sections revealed significantly more labelled cells in eyes treated with laser than in the untreated controls. In addition, cells in neighboring tissues such as iris, ciliary body and sclera showed labelling in association with laser application. Furthermore, comparison of argon-induced lesions with those caused by pulsed Nd:YAG suggests that there are quantitative and qualitative differences in the response of trabecular meshwork and surrounding tissues to these two forms of laser energy.

OSTI ID:
6991368
Journal Information:
Investigative Ophthalmology and Visual Science; (USA), Journal Name: Investigative Ophthalmology and Visual Science; (USA) Vol. 31:1; ISSN 0146-0404; ISSN IOVSD
Country of Publication:
United States
Language:
English

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Related Subjects

550901 -- Pathology-- Tracer Techniques
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTORADIOGRAPHY
AZINES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CELL DIVISION
COMPARATIVE EVALUATIONS
DISEASES
ELECTROMAGNETIC RADIATION
EYES
FACE
GAS LASERS
HEAD
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LASER RADIATION
LASERS
MAMMALS
MEDICINE
MONKEYS
NEODYMIUM LASERS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
PYRIMIDINES
RADIATIONS
RIBOSIDES
SENSE ORGANS
SENSE ORGANS DISEASES
SOLID STATE LASERS
SURGERY
THYMIDINE
TRACER TECHNIQUES
VERTEBRATES