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Chimeric antibody with human constant regions and mouse variable regions directed against carcinoma-associated antigen 17-1A

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
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The authors have cloned the genomic DNA fragments encoding the heavy and light chain variable regions of monoclonal antibody 17-1A, and they have inserted them into mammalian expression vectors containing genomic DNA segments encoding human ..gamma..3 and kappa constant regions. The transfer of these expression vectors containing mouse-human chimeric immunoglobulin genes into Sp2/0 mouse myeloma cells resulted in the production of functional IgG that retained the specific binding to the surface antigen 17-1A expressed on colorectal carcinoma cells.
Research Organization:
Centocor, Malvern, PA
OSTI ID:
5653283
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:1; ISSN PNASA
Country of Publication:
United States
Language:
English

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550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
ATP
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CARCINOMAS
CHEMICAL REACTIONS
CHIMERAS
CLONING
DAYS LIVING RADIOISOTOPES
DISEASES
DNA
DNA SEQUENCING
DNA-CLONING
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
HALOGENATION
IMMUNOTHERAPY
INORGANIC PHOSPHORS
INTERMEDIATE MASS NUCLEI
IODIDES
IODINATION
IODINE 125
IODINE COMPOUNDS
IODINE ISOTOPES
ISOTOPES
LIGHT NUCLEI
LIPOTROPIC FACTORS
MAMMALS
MAN
METHIONINE
MICE
MONOCLONAL ANTIBODIES
MOSAICISM
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
NUCLEOTIDES
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHOSPHORS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PRIMATES
RADIOISOTOPES
RECOMBINANT DNA
RODENTS
SODIUM COMPOUNDS
SODIUM IODIDES
STRUCTURAL CHEMICAL ANALYSIS
SULFUR 35
SULFUR ISOTOPES
THERAPY
TUMOR CELLS
VERTEBRATES