Development of a monoclonal antibody against a tumor-associated antigen

Journal Article · Fri Feb 26 04:00:00 EST 1982 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.7063842· OSTI ID:5678992

Peng, W W; Bressler, J P; Tiffany-Castiglioni, E; De Vellis, J

A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, tranformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultures of astrocytes and oligodendrocytes. The antigen also appears on tumor tissue of transformed oligodendrocytes but not on normal brain tissue.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 5678992
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 215; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
550900 -- Pathology
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGEN-ANTIBODY REACTIONS
ANTIGENS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DISEASES
GLIOMAS
HYBRIDIZATION
MAMMALS
MICE
MONOCLONAL ANTIBODIES
NEOPLASMS
NERVE CELLS
NERVOUS SYSTEM
ONCOGENIC TRANSFORMATIONS
ORGANS
RODENTS
SOMATIC CELLS
TUMOR CELLS
VERTEBRATES