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Interactions between polonium-210 alpha-radiation, benzo(a)pyrene, and 0. 9% NaCl solution instillations in the induction of experimental lung cancer

Journal Article · · Cancer Res.; (United States)
OSTI ID:5643777
; ;

Benzo(a)pyrene and /sup 210/Po were administered both simultaneously and sequentially by intratracheal instillations to Syrian golden hamsters in experiments designed to identify any synergistic interactions between these carcinogens. Their effects were additive after simultaneous administration. A significant synergistic interaction between the two agents appeared to occur when benzo(a)pyrene exposure followed 4 months after /sup 210/Po exposure. Most of this effect could be ascribed, however, to a potentiating effect of subsequent 0.9% NaCl solution instillations on /sup 210/Po carcinogenesis. These results emphasize the fact that seemingly innocuous stimuli may significantly potentiate lung carcinogenesis. The implciations of these findings in terms of the interactions between alpha-radiation and cigarette smoke in human populations are discussed.

Research Organization:
Harvard Univ., Boston, MA
OSTI ID:
5643777
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 38:7; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

550600 -- Medicine
552000 -- Public Health
560151* -- Radiation Effects on Animals-- Man
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AEROSOLS
ALPHA DECAY RADIOISOTOPES
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
COLLOIDS
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DAYS LIVING RADIOISOTOPES
DISEASES
DISPERSIONS
EVEN-EVEN NUCLEI
HAMSTERS
HEAVY NUCLEI
HUMAN POPULATIONS
HYDROCARBONS
ISOTOPES
LUNGS
MAMMALS
NEOPLASMS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
POLONIUM 210
POLONIUM ISOTOPES
POPULATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
SYNERGISM
TOBACCO PRODUCTS
TOBACCO SMOKES
TOXICITY
VERTEBRATES