Effect of dose rate on the induction of experimental lung cancer in hamsters by alpha radiation
The effect of dose rate on the induction of lung cancer in Syrian hamsters by 5.3 MeV alpha particles was examined by varying the number of weekly intratracheal instillations of carrier-free /sup 210/Po. By this technique, most of the radiation dose to the lungs was delivered over intervals ranging from 10 to 120 days. Protraction of exposure over 120 days was slightly more carcinogenic at lower total lung doses (24 rad), but slightly less carcinogenic at higher doses (240 rad), than exposure limited to a 10-day interval. No synergism was observed between very low radiation exposures (2.4 rad) and simultaneously administered benzo(a)pyrene. The carcinogenic effect of a single intratracheal instillation of /sup 210/Po in isotonic saline was markedly enhanced by subsequent weekly instillations of 0.2 ml of saline alone, emphasizing the importance of noncarcinogenic secondary factors in the expression of radiation-induced lung cancer.
- Research Organization:
- Harvard Univ. School of Public Health, Boston, MA
- OSTI ID:
- 5123674
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMALS
AROMATICS
BENZOPYRENE
BODY
CHARGED PARTICLES
CONDENSED AROMATICS
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
DOSES
EVEN-EVEN NUCLEI
EXPERIMENTAL NEOPLASMS
HAMSTERS
HEAVY NUCLEI
HYDROCARBONS
ISOTOPES
LUNGS
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLONIUM 210
POLONIUM ISOTOPES
RADIATION DOSES
RADIOINDUCTION
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SYNERGISM
VERTEBRATES