Boron neutron capture therapy of ocular melanoma and intracranial glioma using p-boronophenylalanine

Conference · Mon Jan 01 00:00:00 EST 1990

OSTI ID:5643007

Coderre, J A; Greenberg, D; Micca, P L; Joel, D D; Saraf, S ^[1]; Packer, S ^[2]

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1. Brookhaven National Lab., Upton, NY (USA)
2. North Shore Univ. Hospital, Manhasset, NY (USA). Div. of Ophthalmology

During conventional radiotherapy, the dose that can be delivered to the tumor is limited by the tolerance of the surrounding normal tissue within the treatment volume. Boron Neutron Capture Therapy (BNCT) represents a promising modality for selective tumor irradiation. The key to effective BNCT is selective localization of {sup 10}B in the tumor. We have shown that the synthetic amino acid p-boronophenylalanine (BPA) will selectively deliver boron to melanomas and other tumors such as gliosarcomas and mammary carcinomas. Systemically delivered BPA may have general utility as a boron delivery agent for BNCT. In this paper, BNCT with BPA is used in treatment of experimentally induced gliosarcoma in rats and nonpigmented melanoma in rabbits. The tissue distribution of boron is described, as is response to the BNCT. 6 refs., 4 figs., 1 tab.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• Sponsoring Organization: USDOE; USDOE, Washington, DC (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5643007
• Report Number(s): BNL-46148; CONF-901226-4; ON: DE91013808
• Resource Relation: Conference: 4. international symposium on neutron capture therapy, Sydney (Australia), 3-7 Dec 1990
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BORON 10
TISSUE DISTRIBUTION
GLIOMAS
NEUTRON CAPTURE THERAPY
MELANOMAS
FEASIBILITY STUDIES
DOSIMETRY
EXPERIMENTAL NEOPLASMS
LABELLED COMPOUNDS
MRR REACTOR
PHENYLALANINE
RABBITS
RATS
SURVIVAL CURVES
AMINO ACIDS
ANIMALS
BORON ISOTOPES
CARBOXYLIC ACIDS
DISEASES
DISTRIBUTION
ENRICHED URANIUM REACTORS
IRRADIATION REACTORS
ISOTOPE PRODUCTION REACTORS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEDICINE
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOLOGY
RADIOTHERAPY
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RODENTS
STABLE ISOTOPES
TANK TYPE REACTORS
THERAPY
THERMAL REACTORS
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
550603* - Medicine- External Radiation in Therapy- (1980-)