Experimental boron neutron capture therapy for melanoma: Systemic delivery of boron to melanotic and amelanotic melanoma

Journal Article · Sun Dec 31 23:00:00 EST 1989 · Pigment Cell Research; (United States)

DOI:https://doi.org/10.1111/j.1600-0749.1990.tb00303.x· OSTI ID:7159763

Coderre, J A; Glass, J D; Micca, P; Greenberg, D ^[1]; Packer, S ^[2]

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1. Brookhaven National Lab., Upton, NY (United States)
2. Brookhaven National Lab., Upton, NY (United States) North Shore University Hospital Manhasset, NY (United States)

The boron-containing melanin precursor analogue p-boronophenylalanine (BPA) has previously been shown to selectively deliver boron to pigmented murine melanomas when administered in a single intragastric dose. If boron neutron capture therapy is to become a clinically useful method of radiation therapy for human malignant melanoma, the boron carrier must be capable of delivering useful amounts of boron to remote tumor sites (metastases) and to poorly pigmented melanomas. The authors have now determined the ability of BPA to accumulate in several nonpigmented melanoma models including human melanoma xenografts in nude mice. The absolute amount of boron in the nonpigmented melanomas was about 50% of the observed in the pigmented counterparts but was still selectively concentrated in the tumor relative to normal tissues in amounts sufficient for effective neutron capture therapy. Single intragastric doses of BPA resulted in selective localization of boron in the amelanotic Greene melanoma carried in the anterior chamber of the rabbit eye and in a pigmented murine melanoma growing in the lungs. The ratio of the boron concentration in these tumors to the boron concentration in the immediately adjacent normal tissue was in the range of 3:1 to 4:1. These distribution studies support the proposal that boron neutron capture therapy may be useful as a regional therapy for malignant melanoma.

• DOE Contract Number: AC02-76CH00016
• OSTI ID: 7159763
• Journal Information: Pigment Cell Research; (United States), Journal Name: Pigment Cell Research; (United States) Vol. 3; ISSN 0893-5785; ISSN PCREE
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BODY
BODY AREAS
BORON 10
BORON ISOTOPES
CARCINOMAS
DISEASES
EPITHELIOMAS
EXPERIMENTAL NEOPLASMS
EYES
FACE
HEAD
ISOTOPES
LIGHT NUCLEI
LUNGS
MAMMALS
MEDICINE
MELANOMAS
MICE
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
RABBITS
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
RODENTS
SENSE ORGANS
STABLE ISOTOPES
THERAPY
VERTEBRATES