Dose-response analysis for boron neutron capture therapy of the B16 murine melanoma using p-boronophenylalanine

Conference · Sun Dec 31 23:00:00 EST 1989

OSTI ID:5546307

Coderre, J A; Micca, P L; Slatkin, D N; Makar, M S

Boron Neutron Capture Therapy (BNCT) of a well-pigmented B16 melanoma implanted subcutaneously in the mouse thigh has been carried out at the Brookhaven Medical Research Reactor (BMRR) using the synthetic amino acid p-boronophenylalanine (BPA) as the boron delivery agent. The response of the B16 melanoma to BNCT was compared with the response to 250 kVp x-rays using both tumor growth delay and in vivo/in vitro assay that measures clonogenic survival. These experiments allow a comparison of tumor growth delay, log cell kill and damage to normal tissues produced by BNCT or photon irradiation.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• Sponsoring Organization: DOE; NIOSH; USDOE, Washington, DC (USA); National Inst. for Occupational Safety and Health, Rockville, MD (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5546307
• Report Number(s): BNL-46150; CONF-901226--5; ON: DE91013806; CNN: CA42446 (JAC)
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BORON 10
BORON ISOTOPES
CARBOXYLIC ACIDS
CELL CULTURES
CELL KILLING
DISEASES
DOSE EQUIVALENTS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
EXPERIMENTAL NEOPLASMS
FAST NEUTRONS
FERMIONS
HADRONS
IMPLANTS
IONIZING RADIATIONS
IRRADIATION REACTORS
ISOTOPE PRODUCTION REACTORS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEDICINE
MELANOMAS
MICE
MRR REACTOR
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NEUTRONS
NITROGEN 14
NITROGEN ISOTOPES
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PERFORMANCE TESTING
PHENYLALANINE
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RBE
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RODENTS
STABLE ISOTOPES
SURVIVAL CURVES
TANK TYPE REACTORS
TESTING
THERAPY
THERMAL REACTORS
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
X RADIATION