Increased dietary cadmium absorption in mice and human subjects with iron deficiency

Journal Article · Mon May 01 04:00:00 EDT 1978 · Gastroenterology; (United States)

OSTI ID:5639846

Flanagan, P R; McLellan, J S; Haist, J; Cherian, G; Chamberlain, M J; Valberg, L S

In mice fed a low iron diet, the addition of low levels of cadmium chloride (10 micrometer) to the drinking water impaired growth and accentuated the development of anemia. Cadmium had no effect on mice given a similar diet supplemented with iron. Iron deficiency increased the concentration of cadmium in the duodenal mucosa, the transfer of cadmium to the body from the intestinal tract, and the deposition of absorbed cadmium in the kidneys. In human subjects, the average absorption of 25 microgram of cadmium, labeled with /sup 115m/Cd, from a test meal was 8.9 +- 2.0% (mean +- SE) in 10 people with low body iron stores (serum ferritin less than 20 ng per ml) and 2.3 +- 0.3% in 12 subjects with normal iron stores (serum ferritin greater than 23 ng per ml). The biological half-time of the radiocadmium in 3 of the subjects ranged from 90 to 202 days. Thus, the intestinal adaptive response to iron deficiency in both experimental animals and human subjects leads to the increased absorption of cadmium, a potentially toxic element.

• Research Organization: University Hospital, London, Canada
• OSTI ID: 5639846
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 74:5; ISSN GASTA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL HALF-LIFE
CADMIUM
CADMIUM 115
CADMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
ELEMENTS
EVEN-ODD NUCLEI
HEMIC DISEASES
INHIBITION
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
IRON
ISOMERIC NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
MICE
NUCLEI
NUTRITIONAL DEFICIENCY
PATIENTS
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
RODENTS
SYMPTOMS
TRACER TECHNIQUES
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES