Effects of iron deficiency on the absorption and distribution of lead and cadmium in rats. [/sup 210/Pb, /sup 109/Cd]

Journal Article · Sat Oct 01 04:00:00 EDT 1977 · J. Lab. Clin. Med.; (United States)

OSTI ID:5339736

Ragan, H A

In order to evaluate the effects of iron deficiency on the absorption of pollutant metals, an iron-deficient diet was fed to young rats until their tissue-iron stores were depleted. Prior to the development of anemia, the iron-deficient rats and littermate controls were administered an intragastric gavage of lead-210 or cadmium-109 and were killed 48 hr later. The body burden of lead was approximately 6 times greater, and that of cadmium approximately 7 times greater, in iron-deficient rats than in the controls. No consistent effects were observed on concentrations of serum total lipids or serum proteins nor on protein electrophoretic patterns in rats with a deficit in iron stores.

• Research Organization: Battelle Pacific Northwest Labs., Richland, WA
• OSTI ID: 5339736
• Journal Information: J. Lab. Clin. Med.; (United States), Journal Name: J. Lab. Clin. Med.; (United States) Vol. 90:4; ISSN JLCMA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA DECAY RADIOISOTOPES
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY BURDEN
CADMIUM
CADMIUM 109
CADMIUM ISOTOPES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
HEAVY NUCLEI
HEMIC DISEASES
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
IRON
ISOTOPES
LEAD
LEAD 210
LEAD ISOTOPES
LIPIDS
MAMMALS
METALS
NUCLEI
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SYMPTOMS
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES