Metabolism of /sup 109/Cd in rats fed normal and low-calcium diets

Journal Article · Thu Jul 01 04:00:00 EDT 1976 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397609529408· OSTI ID:7263469

Washko, P W; Cousins, R J

Growing male rats were fed purified diets that contained either 0.6 percent or 0.1 percent calcium to investigate the relationship of calcium intake to the uptake, tissue distribution, and excretion of /sup 109/Cd. An equal number of rats were fed either the 0.6 or 0.1 percent calcium diets for 4 wk before they were used for experiments. In the first experiment 11 rats from each dietary group were administered 5 ..mu..Ci /sup 109/Cd by stomach tube and were then maintained in metabolism cages for 72 hr. Animals fed the low-calcium diet took up more /sup 109/Cd, as significantly higher levels of radioactivity were found in the intestinal mucosa, serum, lungs, liver, kidneys, and urine and a significantly lower level was found in the feces. Higher levels of /sup 109/Cd, associated with low-molecular-weight proteins that may be related to the absorption process, were found in the intestinal mucosa of the low-calcium group. In the second experiment 10 rats from each dietary group were administered 5 ..mu..Ci /sup 109/Cd by subcutaneous injection and then maintained in a metabolism cage for 72 hr. No significant differences were found in the distribution of excretion of /sup 109/Cd except for the lungs where radioactivity was greater in the low-calcium group. The results of the study indicate that the enhanced cadmium toxicity observed in calcium-deficient animals exposed to the heavy metal is the result of an increased uptake from the small intestine.

• Research Organization: State Univ. of New Jersey, New Brunswick
• OSTI ID: 7263469
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 1:6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560162 -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD SERUM
BODY
BODY FLUIDS
CADMIUM 109
CADMIUM ISOTOPES
CALCIUM
CLEARANCE
DIET
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
EXCRETION
FECES
GASTROINTESTINAL TRACT
GLANDS
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPES
KIDNEYS
LIVER
LUNGS
MAMMALS
METABOLISM
METALS
NUCLEI
ORGANS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
UPTAKE
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES