Influence of iron and zinc status on cadmium accumulation in Bangladeshi women

Journal Article · Sun Jul 15 00:00:00 EDT 2007 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2007.04.009· OSTI ID:20976989

Kippler, Maria ^[1]; Ekstroem, Eva-Charlotte ^[2]; Loennerdal, Bo ^[3]; Goessler, Walter ^[4]; Akesson, Agneta ^[1]; El Arifeen, Shams ^[5]; Persson, Lars-Ake ^[2]; Vahter, Marie ^[1]

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1. Institute of Environmental Medicine, Karolinska Institutet, Stockholm (Sweden)
2. International Maternal and Child Health, Uppsala University, Uppsala (Sweden)
3. Department of Nutrition, University of California, Davis, CA 95616 (United States)
4. Institut fuer Chemie - Analytische Chemie, Karl-Franzens-Universitaet, Graz (Austria)
5. International Centre for Diarrhoeal Disease Research, Bangladesh - ICDDR-B, GPO Box 128, Dhaka 1000 (Bangladesh)

Cadmium is a widespread environmental contaminant present in food. The absorption in the intestine increases in individuals with low iron stores, but the effect of zinc deficiency is not clear. The aim of the present study was to assess the influence of iron and zinc status on cadmium accumulation in pregnant Bangladeshi women. We measured cadmium in urine from 890 women using inductively coupled plasma mass spectrometry (ICPMS). Further, we also measured ferritin and zinc in plasma. The median cadmium concentration in urine was 0.59 {mu}g/L (adjusted to mean specific gravity of 1.012 g/mL). Analysis of covariance (ANCOVA) showed that urinary cadmium was associated with plasma ferritin and plasma zinc via a significant interaction between dichotomized plasma ferritin and plasma zinc. The analysis was adjusted for age and socioeconomic status. Women with low iron stores and adequate zinc status had significantly higher urinary cadmium compared to women with both adequate iron stores and zinc status. There was no difference in urinary cadmium between women with both low iron stores and zinc status compared to those with both adequate iron stores and zinc status. In conclusion, low iron stores were associated with increased cadmium accumulation, but only at adequate zinc status.

• OSTI ID: 20976989
• Journal Information: Toxicology and Applied Pharmacology, Journal Name: Toxicology and Applied Pharmacology Journal Issue: 2 Vol. 222; ISSN TXAPA9; ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ABSORPTION
BIOLOGICAL ACCUMULATION
BLOOD PLASMA
CADMIUM
FERRITIN
FOOD
ICP MASS SPECTROSCOPY
INTESTINES
IRON
URINE
WOMEN
ZINC