Factors influencing intestinal cadmium uptake in pregnant Bangladeshi women-A prospective cohort study
Journal Article
·
· Environmental Research
- Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm (Sweden)
- Institut fuer Chemie-Analytische Chemie, Karl-Franzens-Universitaet, Universitaetsplatz 1, 8010 Graz (Austria)
- Department of Women's and Children's Health, International Maternal and Child Health, Uppsala University, SE-751 85 Uppsala (Sweden)
- Department of Nutrition, University of California, Davis, CA 95616 (United States)
- International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), GPO Box 128, Dhaka 100 (Bangladesh)
Experimental studies indicate that zinc (Zn) and calcium (Ca) status, in addition to iron (Fe) status, affect gastrointestinal absorption of cadmium (Cd), an environmental pollutant that is toxic to kidneys, bone and endocrine systems. The aim of this study was to evaluate how various nutritional factors influence the uptake of Cd in women, particularly during pregnancy. The study was carried out in a rural area of Bangladesh, where malnutrition is prevalent and exposure to Cd via food appears elevated. The uptake of Cd was evaluated by associations between erythrocyte Cd concentrations (Ery-Cd), a marker of ongoing Cd exposure, and concentrations of nutritional markers. Blood samples, collected in early pregnancy and 6 months postpartum, were analyzed by inductively coupled plasma mass spectrometry (ICPMS). Ery-Cd varied considerably (range: 0.31-5.4 {mu}g/kg) with a median of 1.1 {mu}g/kg (approximately 0.5 {mu}g/L in whole blood) in early pregnancy. Ery-Cd was associated with erythrocyte manganese (Ery-Mn; positively), plasma ferritin (p-Ft; negatively), and erythrocyte Ca (Ery-Ca; negatively) in decreasing order, indicating common transporters for Cd, Fe and Mn. There was no evidence of Cd uptake via Zn transporters, but the association between Ery-Cd and p-Ft seemed to be dependent on adequate Zn status. On average, Ery-Cd increased significantly by 0.2 {mu}g/kg from early pregnancy to 6 months postpartum, apparently due to up-regulated divalent metal transporter 1 (DMT1). In conclusion, intestinal uptake of Cd appears to be influenced either directly or indirectly by several micronutrients, in particular Fe, Mn and Zn. The negative association with Ca may suggest that Cd inhibits the transport of Ca to blood.
- OSTI ID:
- 22149205
- Journal Information:
- Environmental Research, Journal Name: Environmental Research Journal Issue: 7 Vol. 109; ISSN ENVRAL; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
Similar Records
Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non-smoking, Norwegian women in the HUNT 2 study
Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron
Relative contribution of CTR1 and DMT1 in copper transport by the blood–CSF barrier: Implication in manganese-induced neurotoxicity
Journal Article
·
Thu Jul 15 00:00:00 EDT 2010
· Environmental Research
·
OSTI ID:22149221
Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron
Journal Article
·
Tue Jul 15 00:00:00 EDT 2008
· Toxicology and Applied Pharmacology
·
OSTI ID:21140891
Relative contribution of CTR1 and DMT1 in copper transport by the blood–CSF barrier: Implication in manganese-induced neurotoxicity
Journal Article
·
Tue May 01 00:00:00 EDT 2012
· Toxicology and Applied Pharmacology
·
OSTI ID:22215307