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U.S. Department of Energy
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Quantification of ischemic and infarcted myocardium. Report no. 9 (final), 30 jun 75-31 dec 77

Technical Report ·
OSTI ID:5639655
An instrument for positron emission tomography has been developed in collaboration with G. Muehllehner of Searle Radiographics Inc. which consists of two modified gamma cameras mounted in a rotating gantry and connected in coincidence. The electronic and mechanical development was carried out by Searle, the testing, software development and initial trials were a collaborative effort. The principal accomplishments consisted of: Demonstration of the practicality of myocardial imaging with a variety of agents 81Rb+, 13 0Cs+, 13NH4+, N-13 asparagine; software was developed which permitted quantitative tomography both in transverse and longitudinal modes; validation studies were carried out in a porcine model demonstrating that 13NH4+ uptake appears to be a good marker for flow, and clinical pilot studies in recovering, ambulatory patients with myocardial infarction demonstrated vastly improved visualization of the myocardium.
Research Organization:
Chicago Univ., IL (USA). Pritzker School of Medicine
OSTI ID:
5639655
Report Number(s):
PB-293737
Country of Publication:
United States
Language:
English