Evaluation of genotoxic effects of the herbicide dicamba using in vivo and in vitro test systems
Journal Article
·
· Environmental and Molecular Mutagenesis; (USA)
- Universita di Bologna (Italy)
The genotoxic effects of the herbicide dicamba have been studied by measuring (1) the unwinding rate of liver DNA from intraperitoneally treated rats (fluorimetric assay); (2) DNA repair as unscheduled DNA synthesis (UDS) induced in cultured human peripheral blood lymphocytes (HPBL); and (3) sister chromatid exchanges (SCE) in HPBL. Results show that dicamba is capable of inducing DNA damage since it significantly increases the unwinding rate of rat liver DNA in vivo and also induces UDS in HPBL in vitro in the presence of exogenous metabolic activation (S-9 mix). Furthermore, dicamba causes a very slight increase in SCE frequency in HPBL in vitro.
- OSTI ID:
- 5639030
- Journal Information:
- Environmental and Molecular Mutagenesis; (USA), Journal Name: Environmental and Molecular Mutagenesis; (USA) Vol. 15:3; ISSN 0893-6692; ISSN EMMUE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BENZOIC ACID
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DNA REPAIR
DNA REPLICATION
GLANDS
HERBICIDES
HYDROGEN COMPOUNDS
IN VIVO
LEUKOCYTES
LIVER
LYMPHOCYTES
MAMMALS
MATERIALS
METABOLIC ACTIVATION
MONOCARBOXYLIC ACIDS
MUTATIONS
NUCLEIC ACID REPLICATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PESTICIDES
RATS
RECOVERY
REPAIR
RODENTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TRITIUM COMPOUNDS
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BENZOIC ACID
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DNA REPAIR
DNA REPLICATION
GLANDS
HERBICIDES
HYDROGEN COMPOUNDS
IN VIVO
LEUKOCYTES
LIVER
LYMPHOCYTES
MAMMALS
MATERIALS
METABOLIC ACTIVATION
MONOCARBOXYLIC ACIDS
MUTATIONS
NUCLEIC ACID REPLICATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PESTICIDES
RATS
RECOVERY
REPAIR
RODENTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TRITIUM COMPOUNDS
VERTEBRATES