In vitro genotoxicity of chlorinated drinking water processed from humus-rich surface water
Journal Article
·
· Bull. Environ. Contam. Toxicol.; (United States)
Chlorination by-products of drinking waters are capable of inducing sister chromatid exchanges (SCE) and chromosome aberrations (CA) in vitro, in addition to their mutagenic activity in the Ames test. Finnish drinking waters, processed from humus-rich surface water using chlorine disinfection, have been found to be highly mutagenic in the Ames' test. The highest activities have been found in the acidic, non-volatile fraction of the water concentrates using tester strain TA100 without metabolic activation by S9mix. The mutagenicities have varied between 500 and 14,000 induced revertants per liter. These figures are one to two magnitudes higher than those reported elsewhere. The authors studied five Finnish drinking water samples for their potency to exert genotoxic effects, SCEs and CAs, in mammalian cells in vitro (human peripheral lymphocytes and Chinese hamster lung fibroblasts).
- Research Organization:
- National Public Health Institute, Kuopio (Finland)
- OSTI ID:
- 6396241
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 41:5; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Genotoxicity of drinking water from Chao Lake
Contribution of chlorination to the mutagenic activity of drinking water extracts in Salmonella and Chinese hamster ovary cells
Effects of human placental S9 and induced rat liver S9 on the mutagenicity of drinking waters processed from humus-rich surface waters
Journal Article
·
Sun Jan 31 23:00:00 EST 1999
· Environmental Research
·
OSTI ID:347664
Contribution of chlorination to the mutagenic activity of drinking water extracts in Salmonella and Chinese hamster ovary cells
Journal Article
·
Fri Oct 31 23:00:00 EST 1986
· Environ. Health Perspect.; (United States)
·
OSTI ID:5758136
Effects of human placental S9 and induced rat liver S9 on the mutagenicity of drinking waters processed from humus-rich surface waters
Journal Article
·
Sun Dec 31 23:00:00 EST 1989
· Environmental and Molecular Mutagenesis; (USA)
·
OSTI ID:5848352
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHEMICAL REACTIONS
CHLORINATION
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DRINKING WATER
EUROPE
FIBROBLASTS
FINLAND
GENETIC EFFECTS
HALOGENATION
HYDROGEN COMPOUNDS
LEUKOCYTES
LUNGS
LYMPHOCYTES
MATERIALS
METABOLIC ACTIVATION
MUTAGEN SCREENING
MUTATIONS
ORGANS
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
SCANDINAVIA
SCREENING
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
WATER
WESTERN EUROPE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHEMICAL REACTIONS
CHLORINATION
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DRINKING WATER
EUROPE
FIBROBLASTS
FINLAND
GENETIC EFFECTS
HALOGENATION
HYDROGEN COMPOUNDS
LEUKOCYTES
LUNGS
LYMPHOCYTES
MATERIALS
METABOLIC ACTIVATION
MUTAGEN SCREENING
MUTATIONS
ORGANS
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
SCANDINAVIA
SCREENING
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
WATER
WESTERN EUROPE