Effects of human placental S9 and induced rat liver S9 on the mutagenicity of drinking waters processed from humus-rich surface waters

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Environmental and Molecular Mutagenesis; (USA)

DOI:https://doi.org/10.1002/em.2850150405· OSTI ID:5848352

Vartiainen, T; Lampelo, S ^[1]

---

1. National Public Health Institute, Kuopio (Finland)

The mutagenicity of chlorinated drinking waters processed from humus-rich surface waters has been shown to be very high. The effect of placental S9 on the mutagenicity of drinking waters has not been studied previously. The purpose of this study was to compare the effects of human placental and rat liver microsomal fractions on the mutagenicity of drinking waters processed from humus-rich surface waters. The samples of 34 drinking and two raw waters from 26 localities in Finland were tested for mutagenicity in Ames Salmonella typhimurium tester strain TA100 with and without metabolic activations. Between the drinking water samples, clear differences were recorded in the presence of placental and rat liver S9, suggesting different mutagens in the drinking waters. Rat liver S9 decreased the mutagenicities of drinking water concentrates, but placental S9 increased, decreased, or had no effect. It is not known if placental mutagenicity enhancing system might cause any health hazard to a developing fetus.

• OSTI ID: 5848352
• Journal Information: Environmental and Molecular Mutagenesis; (USA), Journal Name: Environmental and Molecular Mutagenesis; (USA) Vol. 15:4; ISSN 0893-6692; ISSN EMMUE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BACTERIA
BODY
CELL CONSTITUENTS
CHEMICAL REACTIONS
CHLORINATION
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DRINKING WATER
EUROPE
FETAL MEMBRANES
FINLAND
GLANDS
HALOGENATION
HUMUS
HYDROGEN COMPOUNDS
LIVER
MAMMALS
MAN
MEMBRANES
MICROORGANISMS
MICROSOMES
MUTAGEN SCREENING
MUTAGENESIS
MUTANTS
ORGANOIDS
ORGANS
OXYGEN COMPOUNDS
PLACENTA
PRIMATES
RATS
REVERTANTS
RIBOSOMES
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCANDINAVIA
SCREENING
SURFACE WATERS
VERTEBRATES
WATER
WESTERN EUROPE