Assay-specific genotoxicity of N-nitrosodibenzylamine to the rat liver in vivo
Journal Article
·
· Environmental and Molecular Mutagenesis; (USA)
- German Cancer Research Centre, Heidelberg (West Germany)
- ICI Central Toxicology Laboratory, Cheshire (England)
- Polysar Ltd., Sarnia, Ontario (Canada)
N-Nitrosodibenzylamine (NDBzA) is mutagenic to Salmonella typhimurium and induces DNA strand breaks in isolated rat hepatocytes, yet it is reported to be non-carcinogenic to the rat. Here the authors report that it is inactive in both the rat and mouse bone marrow micronucleus assays and in a rat liver autoradiographic assay for unscheduled DNA synthesis. It is, however, clearly active as a micronucleus-inducing agent and mitogen in the rat liver and is capable of inducing single-strand breaks in the DNA of rat liver. The origin and implications of this curious conflict of in vivo genotoxicity data are discussed. Irrespective of that discussion, it is concluded that NDBzA is genotoxic to the rat liver in vivo.
- OSTI ID:
- 5840064
- Journal Information:
- Environmental and Molecular Mutagenesis; (USA), Journal Name: Environmental and Molecular Mutagenesis; (USA) Vol. 15:4; ISSN 0893-6692; ISSN EMMUE
- Country of Publication:
- United States
- Language:
- English
Similar Records
In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
Genotoxicity of the phosphoramidate agent tabun (Ga). (Reannouncement with new availability information)
Comparison of three in vitro assays for carcinogen-induced DNA damage. [Rats]
Journal Article
·
Fri Jun 01 00:00:00 EDT 2012
· Toxicology and Applied Pharmacology
·
OSTI ID:22215325
Genotoxicity of the phosphoramidate agent tabun (Ga). (Reannouncement with new availability information)
Technical Report
·
Fri Dec 30 23:00:00 EST 1994
·
OSTI ID:210768
Comparison of three in vitro assays for carcinogen-induced DNA damage. [Rats]
Journal Article
·
Fri Feb 29 23:00:00 EST 1980
· J. Toxicol. Environ. Health; (United States)
·
OSTI ID:5448026
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
BACTERIA
BIOASSAY
BIOLOGICAL EFFECTS
BODY
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DNA
DNA REPLICATION
GENETIC EFFECTS
GLANDS
IN VIVO
LIVER
MAMMALS
METABOLISM
MICROORGANISMS
NITROSAMINES
NITROSO COMPOUNDS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RATS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SOMATIC CELLS
STRAND BREAKS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
BACTERIA
BIOASSAY
BIOLOGICAL EFFECTS
BODY
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DNA
DNA REPLICATION
GENETIC EFFECTS
GLANDS
IN VIVO
LIVER
MAMMALS
METABOLISM
MICROORGANISMS
NITROSAMINES
NITROSO COMPOUNDS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RATS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SOMATIC CELLS
STRAND BREAKS
VERTEBRATES