Assay-specific genotoxicity of N-nitrosodibenzylamine to the rat liver in vivo
- German Cancer Research Centre, Heidelberg (West Germany)
- ICI Central Toxicology Laboratory, Cheshire (England)
- Polysar Ltd., Sarnia, Ontario (Canada)
N-Nitrosodibenzylamine (NDBzA) is mutagenic to Salmonella typhimurium and induces DNA strand breaks in isolated rat hepatocytes, yet it is reported to be non-carcinogenic to the rat. Here the authors report that it is inactive in both the rat and mouse bone marrow micronucleus assays and in a rat liver autoradiographic assay for unscheduled DNA synthesis. It is, however, clearly active as a micronucleus-inducing agent and mitogen in the rat liver and is capable of inducing single-strand breaks in the DNA of rat liver. The origin and implications of this curious conflict of in vivo genotoxicity data are discussed. Irrespective of that discussion, it is concluded that NDBzA is genotoxic to the rat liver in vivo.
- OSTI ID:
- 5840064
- Journal Information:
- Environmental and Molecular Mutagenesis; (USA), Journal Name: Environmental and Molecular Mutagenesis; (USA) Vol. 15:4; ISSN 0893-6692; ISSN EMMUE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
BACTERIA
BIOASSAY
BIOLOGICAL EFFECTS
BODY
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DNA
DNA REPLICATION
GENETIC EFFECTS
GLANDS
IN VIVO
LIVER
MAMMALS
METABOLISM
MICROORGANISMS
NITROSAMINES
NITROSO COMPOUNDS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RATS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SOMATIC CELLS
STRAND BREAKS
VERTEBRATES