Genotoxicity of the phosphoramidate agent tabun (Ga). (Reannouncement with new availability information)
Technical Report
·
OSTI ID:210768
Five mutagenicity tests were performed on Agent GA (Tabun, phosphoramidocyanidic acid, dimethyl-, ethyl ester) as part of a program to demilitarize chemical warfare agents. GA was mutagenic in Salmonella spp. assays with S-9 and it was a direct-acting mutagen to mouse lymphoma cells. GA did not promote unscheduled DNA synthesis in rat hepatocytes; it induced sister chromatid exchanges in mouse cells in vitro but not in vivo. The conclusion that GA is a weakly acting mutagen is supported by the fact that it was mutagenic in only three of the five assays, and that increases in mutagenicity were often less than 2-fold the controls and occurred near toxic levels. Tabun, Agent GA, Phosphoroamidocyanidic acid, Dimethyl-, Ethyl ester, Genotoxicity, Mutagenic assays.
- Research Organization:
- Army Biomedical Research and Development Lab., Fort Detrick, MD (United States)
- OSTI ID:
- 210768
- Report Number(s):
- AD-A--278602/8/XAB
- Country of Publication:
- United States
- Language:
- English
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