Zinc as an integral component of the metabolic response to trauma. [Rats]
Journal Article
·
· Somatic Cell Genet.; (United States)
OSTI ID:5635187
Following injury, there is a major redistribution of zinc, as demonstrated by /sup 65/Zn tracer studies in rats receiving 20 per cent burns. This injury resulted in a rapid uptake of /sup 65/Zn into spleen, lung, wound, kidney and, particularly, liver, while the uptake of /sup 65/Zn was decreased in the brain, some muscle groups and, particularly, in bone. Simultaneously, plasma /sup 65/Zn occurred predominantly as the albumin bound fraction decreased. The total amount of tracer appearing in the wound was considerably less than that in the liver, where the induction of zinc binding protein was demonstrated in the cytosol. The synthesis of this protein may have an important regulatory role in zinc homeostasis following injury. These widespread changes in /sup 65/Zn distribution are consistent with the essential role of zinc in numerous metabolic processes and the increased metabolic activity of such tissues as the liver and the wound that follows injury. It is apparent that the liver has a central role in the early postinjury changes in zinc metabolism and that bone as well as muscle provides an available source of zinc in these circumstances.
- Research Organization:
- Department of Surgery, East Carolina University School of Medicine, Greenville, North Carolina
- OSTI ID:
- 5635187
- Journal Information:
- Somatic Cell Genet.; (United States), Journal Name: Somatic Cell Genet.; (United States) Vol. 153:5; ISSN SCEGD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
BURNS
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
INJURIES
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LIVER
LUNGS
MAMMALS
NERVOUS SYSTEM
NUCLEI
ORGANS
PHYSIOLOGY
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RESPIRATORY SYSTEM
RODENTS
SKELETON
SPLEEN
TISSUE DISTRIBUTION
VERTEBRATES
WOUNDS
ZINC 65
ZINC ISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
BURNS
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
INJURIES
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LIVER
LUNGS
MAMMALS
NERVOUS SYSTEM
NUCLEI
ORGANS
PHYSIOLOGY
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RESPIRATORY SYSTEM
RODENTS
SKELETON
SPLEEN
TISSUE DISTRIBUTION
VERTEBRATES
WOUNDS
ZINC 65
ZINC ISOTOPES