Effects of inflammation on copper, iron, and zinc metabolism

Journal Article · Wed Mar 05 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:7024675

Kishore, V; Ochillo, R F

The objective of the present study was to study changes in copper (Cu), iron (Fe), and zinc (Zn) metabolism due to acute and chronic inflammation in the rat. Carrageenin-induced foot edema (CE) and adjuvant-induced arthritis (AA) were used as models as acute and chronic inflammation, respectively. A non-inflamed control group was included in each study. Rats were sacrificed 72 h post-carrageenin in the CE study, and 21 days post-adjuvant in the AA study. Samples of bone, brain, heart, kidney, liver, lung, muscle, pancreas, plasma, and spleen were analyzed for Cu, Zn, and Fe by atomic absorption spectrometry. Only those metal conc. in the inflamed group which showed a significant change with respect to the corresponding control group are reported. In the CE study: 1) Cu conc. increased in pancreas(75%), lungs(74%), and kidneys(47%), and decreased in the spleen(22%); 2) Zn conc. increased in pancreas(25%), lungs(27%), and in kidneys(18%); and 3) Fe conc. increased in pancreas(50%), lungs(21%), liver(26%), and brain(17%), and decreased in the muscle(21%). In the AA study: 1) Cu conc. increased in plasma(159%), liver(126%). pancreas(90%), lungs(42%), bone(22%) and in the brain(13%); 2) Zn conc. increased in the liver(88%), pancreas(77%), and in kidneys(15%); and 3) Fe conc. increased in the liver(43%), pancreas(66%), and in the brain(31%). Results indicate that both acute and chronic inflammation have a pronounced effect on Cu, Zn, and Fe metabolism.

• Research Organization: Xavier Univ. of Louisiana, New Orleans
• OSTI ID: 7024675
• Report Number(s): CONF-8604222-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:4; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTROSCOPY
ANIMALS
BIOLOGICAL EFFECTS
COPPER
DISTRIBUTION
ELEMENTS
INFLAMMATION
IRON
MAMMALS
METABOLISM
METALS
PATHOLOGICAL CHANGES
RATS
RODENTS
SPECTROSCOPY
SYMPTOMS
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
VERTEBRATES
ZINC