Effect of dietary calcium and phosphorus on intestinal calcium absorption and vitamin D metabolism

Journal Article · Mon May 01 00:00:00 EDT 1978 · Arch. Biochem. Biophys.; (United States)

DOI:https://doi.org/10.1016/0003-9861(78)90367-3· OSTI ID:5634275

Ribovich, M L; DeLuca, H F

To understand better dietary regulation of intestinal calcium absorption, a quantitative assessment of the metabolites in plasma and duodenum of rats given daily doses of radioactive vitamin D/sub 3/ and diets differing in calcium and phosphorus content was made. All known vitamin D metabolites were ultimately identified by high-pressure liquid chromatography. In addition to the known metabolites (25-hydroxyvitamin D/sub 3/, 24,25-dihydroxyvitamin D/sub 3/, 1,25-dihydroxyvitamin D/sub 3/, 25,26-dihydroxyvitamin D/sub 3/, and 1,24,25-trihydroxyvitamin D/sub 3/), several new and unidentified metabolites were found. In addition to 1,25-dihydroxyvitamin D/sub 3/ and 1,24,25-trihydroxyvitamin D/sub 3/, the levels of some of the unknown metabolites could be correlated with intestinal calcium transport. However, whether or not any of these metabolites plays a role in the stimulation of intestinal calcium absorption by low dietary calcium or low dietary phosphorus remains unknown.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 5634275
• Journal Information: Arch. Biochem. Biophys.; (United States), Vol. 188:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CALCIUM
INTESTINAL ABSORPTION
CHOLECALCIFEROL
METABOLISM
PHOSPHORUS
DIET
STIMULATION
TRITIUM
ALKALINE EARTH METALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
ELEMENTS
HYDROGEN ISOTOPES
ISOTOPES
LIGHT NUCLEI
METALS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
UPTAKE
VITAMIN D
VITAMINS
YEARS LIVING RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques
550201 - Biochemistry- Tracer Techniques
550501 - Metabolism- Tracer Techniques