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Metabolism and biological activity of 24,25-dihydroxyvitamin D/sub 3/ in the chick

Journal Article · · J. Biol. Chem.; (United States)
OSTI ID:5852306
; ; ; ;

The vitamin, 24R,24,25-dihydroxyvitamin D/sub 3/, is capable of inducing a minimal intestinal calcium transport response in chicks when compared to an equal amount of 25-hydroxyvitamin D/sub 3/. 1,24,25-Trihydroxyvitamin D/sub 3/ is also less active than 1,25-dihydroxyvitamin D/sub 3/, and its activity is much shorter lived than that of 1,25-dihydroxyvitamin D/sub 3/. A comparison of the metabolism of 25-hydroxy(26,27-/sup 3/H)vitamin D/sub 3/ and 24,25-dihydroxy(26,27-/sup 3/H)vitamin D/sub 3/ in the rat and chick shows that 24,25-dihydroxyvitamin D/sub 3/ and 1,24,25-trihydroxyvitamin D/sub 3/ disappear at least 10 times more rapidly from the blood and intestine of chicks. Furthermore, examination of the excretory products from both of these species demonstrates that chicks receiving a single dose of 24,25-dihydroxy(26,27-/sup 3/H)vitamin D/sub 3/ excrete 66% of the total radioactivity by 48 hours, whereas rats receiving the same dose excrete less than one-half that amount. These results demonstrate that 24,25-dihydroxyvitamin D/sub 3/ is considerably less biologically active in the chick than in the rat, probably due to more rapid metabolism and excretion.

Research Organization:
Univ. of Wisconsin, Madison
OSTI ID:
5852306
Journal Information:
J. Biol. Chem.; (United States), Journal Name: J. Biol. Chem.; (United States) Vol. 251:2; ISSN JBCHA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
550501 -- Metabolism-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL VARIABILITY
BIRDS
BODY
CALCIUM
CHICKENS
CHOLECALCIFEROL
CLEARANCE
DIGESTIVE SYSTEM
ELEMENTS
EXCRETION
FOWL
GASTROINTESTINAL TRACT
HYDROGEN ISOTOPES
HYDROXYLATION
INTESTINAL ABSORPTION
INTESTINES
ISOTOPES
LIGHT NUCLEI
MAMMALS
METABOLISM
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RATS
RODENTS
TRITIUM
UPTAKE
VERTEBRATES
VITAMIN D
VITAMINS
YEARS LIVING RADIOISOTOPES