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Bone marrow reconstitution of immune responses following irradiation in the leopard frog, Rana pipiens

Journal Article · · Dev. Comp. Immunol.; (United States)
OSTI ID:5622007
; ;
The bone marrow of Rana is an important source of cells capable of maintaining individual viability, responding to Concanavalin A (Con A) and producing PFC against sheep erythrocyte (SRBC) antigens. Frog marrow is more effective than the spleen in maintaining life. Radiation destroys the ability of frogs to respond to SRBC immunization (lack of bone marrow and spleen PFC, serum antibody) and bone marrow/spleen cells to respond to Con A, i.e., bone marrow and spleen contain radiation-sensitive cells. Shielding one hind leg during irradiation leads to reconstitution of bone marrow/spleen PFC responses, antibody synthesis and individual viability. Our results suggest that bone marrow is: a) the source of stem cells, and b) the source of mature T- and B- lymphocytes that can recirculate within the immune system.
Research Organization:
Department of Anatomy, School of Medicine, University of California, Los Angeles
OSTI ID:
5622007
Journal Information:
Dev. Comp. Immunol.; (United States), Journal Name: Dev. Comp. Immunol.; (United States) Vol. 7:2; ISSN DCIMD
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
AMPHIBIANS
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
AQUATIC ORGANISMS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW CELLS
CHIMERAS
CONCANAVALIN
CONNECTIVE TISSUE CELLS
FROGS
GLOBULINS
HEMAGGLUTININS
IMMUNOGLOBULINS
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MOSAICISM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
SOMATIC CELLS
SPLEEN
SYNTHESIS
VERTEBRATES