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Ataxia-telangiectasia homo- and heterozygous cells show a normal repair and fixation response to anisotonic NaCl treatment after irradiation

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576509· OSTI ID:5614166
;
The effect of anisotonic NaCl treatment on fixation and repair of radiation-induced potentially lethal damage (PLD) was tested in normal human cells and in three homozygous ataxia-telangiectasia (A-T) and two heterozygous A-T cells strains. This effect was observed in both plateau-phase and exponentially growing normal and A-T cells. When an incubation period at 37/sup 0/C was introduced between irradiation and the subsequent anisotonic treatment, recovery was observed in both normal and A-T cells strains. These data show that A-T cells are as proficient as normal cells in repairing PLD that is sensitive to anisotonic NaCl treament. It is proposed that two PLD repair systems may exist, one that is expressed after irradiation in proliferatively arrested cells and another that occurs in plateau-phase as well as exponentially growing cells.
Research Organization:
Atomic Energy of Canada Ltd. Research Co., Pinawa, Manitoba
OSTI ID:
5614166
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 101:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL KILLING
CHLORIDES
CHLORINE COMPOUNDS
CONNECTIVE TISSUE CELLS
DATA
DISEASES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FIBROBLASTS
HALIDES
HALOGEN COMPOUNDS
INFORMATION
IONIZING RADIATIONS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SKIN DISEASES
SODIUM CHLORIDES
SODIUM COMPOUNDS
SOMATIC CELLS
SURVIVAL CURVES
TELANGIECTASIS
VASCULAR DISEASES
X RADIATION