Clinical and treatment effects on /sup 3/H-clonidine and /sup 3/H-imipramine binding in elderly depressed patients
/sup 3/H-clonidine and /sup 3/H-imipramine binding were measured in depressed patients, 55 years and older. There was no significant difference in either /sup 3/H-clonidine or /sup 3/H-imipramine binding between depressed patients and age- and sex-matched controls. There was no significant correlation between /sup 3/H-clonidine or /sup 3/H-imipramine binding and severity of depression before treatment. There was a significant negative correlation between the K/sub D/ of /sup 3/H-imipramine binding sites and Hamilton score over seven weeks of antidepressant treatment. There was no significant difference between receptor data of responders and nonresponders to antidepressant treatment. 19 references, 2 tables.
- Research Organization:
- New York Univ. School of Medicine, NY
- OSTI ID:
- 5607500
- Journal Information:
- Life Sci.; (United States), Vol. 40:22
- Country of Publication:
- United States
- Language:
- English
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ANTIDEPRESSANTS
BIOCHEMICAL REACTION KINETICS
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AGED ADULTS
NERVOUS SYSTEM DISEASES
PATIENTS
TRACER TECHNIQUES
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CENTRAL NERVOUS SYSTEM AGENTS
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DRUGS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
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550201* - Biochemistry- Tracer Techniques