Acute pulmonary effects of formaldehyde exposure in humans. Progress report, December 1, 1983-November 30, 1984

Technical Report · Mon Jul 01 00:00:00 EDT 1985

OSTI ID:5607315

Nonsmoking subjects were randomly exposed at rest for 3 hours each to 0.0, 0.5, 1.0, and 2.0 ppM HCHO for establishing a dose-response curve at rest, and in addition, the effect of 2 ppM HCHO with moderate exercise (V/sub E/ = 30-40 L/min) with a 24-hr post exposure was evaluated. Results of exposure of the 10 subjects to these concentrations are: (1) a signifiant or near significant decrease, compared to clean air (0.0 ppM HCHO); in log PD/sub 35SGaw/ with exposure to 2.0 ppM HCHO at rest; log PD/sub SGaw/ and FEV/sub 1/ at 24-hours after the 2.0 ppM HCHO exposure with exercise; (2) the FVC and FEV/sub 1/ time courses of response showed no clear change in function over any 3-hour exposure from 0.0 to 2.0 ppM HCHO; and (3) including the 2.0 ppM HCHO exposure only mild symptoms (primarily eye and nose-throat irritation) were experienced by these subjects. 3 refs., 1 fig.

• Research Organization: Maryland Univ., Baltimore (USA)
• DOE Contract Number: AS05-84ER60192
• OSTI ID: 5607315
• Report Number(s): DOE/ER/60192-1; ON: DE85014728
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
COLLOIDS
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
EXERCISE
FORMALDEHYDE
MAMMALS
MAN
ORGANIC COMPOUNDS
PRIMATES
RESIDUES
RESPIRATION
SMOKES
SOLS
TOBACCO SMOKES
VERTEBRATES