Acute pulmonary effects of formaldehyde exposure in humans: Final technical report
Technical Report
·
OSTI ID:7125462
Irritation of the eyes and upper respiratory tract is the predominant symptom reported in association with low-level HCHO exposure, with bronchoconstriction reported in some individuals. There has been no systematic investigation of the symptomatic and pulmonary function response to HCHO in humans over the range of concentrations found in the home and occupational setting. In a three year study of normal nonsmoking and asthmatic subjects, we observed that some individuals will experience eye and upper respiratory tract irritation at HCHO levels of 0.5 ppM and above. Inhalation of HCHO at concentrations up to 3 ppM at rest was not associated with pulmonary function decrements or increased bronchial reactivity. Asthmatic subjects engaging in moderate exercise at 3 ppM HCHO showed no group decrements in lung function; whereas, normal nonsmoking individuals engaging in heavy exercise at 3 ppM HCHO produced small decrements in lung function. Simultaneous HCHO and carbon aerosol exposure produced small, synergistic decrements in lung function. A subset of individuals was identified who display a greater than average responsiveness to HCHO.
- Research Organization:
- Maryland Univ., Baltimore (USA). Dept. of Medicine
- DOE Contract Number:
- AS05-84ER60192
- OSTI ID:
- 7125462
- Report Number(s):
- DOE/ER/60192-4; ON: DE88014644
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ALDEHYDES
ANIMALS
ATMOSPHERES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CONTROLLED ATMOSPHERES
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
ECOLOGICAL CONCENTRATION
EXERCISE
EYES
FACE
FORMALDEHYDE
HAZARDS
HEAD
HEALTH HAZARDS
INHALATION
INTAKE
LUNGS
MAMMALS
MAN
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROGRESS REPORT
RESPIRATORY SYSTEM
SENSE ORGANS
VERTEBRATES
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ALDEHYDES
ANIMALS
ATMOSPHERES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CONTROLLED ATMOSPHERES
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
ECOLOGICAL CONCENTRATION
EXERCISE
EYES
FACE
FORMALDEHYDE
HAZARDS
HEAD
HEALTH HAZARDS
INHALATION
INTAKE
LUNGS
MAMMALS
MAN
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROGRESS REPORT
RESPIRATORY SYSTEM
SENSE ORGANS
VERTEBRATES