Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium
Journal Article
·
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
- Johns Hopkins Univ. School of Medicine, Baltimore, MD (USA)
The authors report the stoichiometric phosphorylation of an inositol 1,4,5-trisphosphate receptor-binding protein from rat brain by the cAMP-dependent protein kinase but not by protein kinase C or Ca{sup 2+}/calmodulin-dependent protein kinase. This phosphorylation event does not markedly alter ({sup 3}H)inositol 1,4,5-trisphosphate-binding characteristics. However, inositol 1,4,5-trisphosphate is only 10% as potent in releasing {sup 45}Ca{sup 2+} from phosphorylated, as compared with native, cerebellar microsomes. Phosphorylation of the inositol 1,4,5-trisphosphate-binding protein by the cAMP-dependent protein kinase may provide a biochemical substrate for second-messenger cross talk.
- OSTI ID:
- 5607297
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 85:22; ISSN 0027-8424; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Sat Jan 31 23:00:00 EST 1987
· Am. J. Physiol.; (United States)
·
OSTI ID:6285084
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
AMP
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CALCIUM 45
CALCIUM ISOTOPES
CARBOHYDRATES
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CHEMICAL REACTIONS
CROSS-LINKING
DAYS LIVING RADIOISOTOPES
ENZYMES
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
INOSITOLS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEMBRANE PROTEINS
MICROSOMES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHORYLATION
PHOSPHOTRANSFERASES
POLYMERIZATION
PROTEINS
PURIFICATION
RADIOISOTOPES
RATS
RECEPTORS
RIBOSOMES
RODENTS
SACCHARIDES
SECRETION
STOICHIOMETRY
TRANSFERASES
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
AMP
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CALCIUM 45
CALCIUM ISOTOPES
CARBOHYDRATES
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CHEMICAL REACTIONS
CROSS-LINKING
DAYS LIVING RADIOISOTOPES
ENZYMES
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
INOSITOLS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEMBRANE PROTEINS
MICROSOMES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHORYLATION
PHOSPHOTRANSFERASES
POLYMERIZATION
PROTEINS
PURIFICATION
RADIOISOTOPES
RATS
RECEPTORS
RIBOSOMES
RODENTS
SACCHARIDES
SECRETION
STOICHIOMETRY
TRANSFERASES
TRITIUM COMPOUNDS
VERTEBRATES