Biliary excretion of intravenous (/sup 14/C) omeprazole in humans

Journal Article · Sat Oct 31 23:00:00 EST 1987 · Clin. Pharmacol. Ther.; (United States)

DOI:https://doi.org/10.1038/clpt.1987.188· OSTI ID:5606562

Lind, T; Andersson, T; Skanberg, I O; Olbe, L

We have studied the biliary excretion of (/sup 14/C) omeprazole in humans. The study was performed in eight healthy subjects and the technique used was based on multiple marker dilution principles with double-lumen tubes placed in both the stomach and intestine. The results obtained show a 16% biliary excretion of (/sup 14/C) omeprazole. These data suggest a minimal spillover of omeprazole from the gastric mucosa into the gastric lumen in humans. The results also agree with previous data of the fecal recovery of radiolabeled omeprazole that suggest that the fecal excretion of intravenous omeprazole in humans is entirely accounted for by biliary excretion.

• Research Organization: Sahlgrenska Sjukhuset, Goeteborg, Sweden
• OSTI ID: 5606562
• Journal Information: Clin. Pharmacol. Ther.; (United States), Journal Name: Clin. Pharmacol. Ther.; (United States) Vol. 42:5; ISSN CLPTA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AZOLES
BILE
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
CLEARANCE
DIGESTIVE SYSTEM
EXCRETION
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
INJECTION
INTAKE
INTESTINES
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MAN
MATERIALS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
PYRROLES
STOMACH
TRACER TECHNIQUES
VERTEBRATES