Distribution of nitrogen-13 from labeled nitrate (/sup 13/NO/sub 3//sup -/) in humans and rats
The body distribution of gavaged or intravenously administered nitrate labeled with nitrogen-13 was studied in humans and rats with the following results: (1) the labeled compound is not quickly absorbed from the stomach; (2) the concentration of the label increases inside the lower intestinal tract (cecum and large intestine) when ingested or intravenously injected; and (3) humans and rats have the capacity to store a portion of the label in their bodies. These observations indicate that depletion of body stores, the passage of nitrate down the gut, or the secretion of nitrate into the intestinal lumen may be a better explanation of the urinary, ileal, and fecal concentrations of nitrate and nitrate recently measured in humans than a bacterial nitrification reaction in the intestines, as suggested by Tannenbaum, et al.
- Research Organization:
- Univ. of Wisconsin Medical School, Madison
- OSTI ID:
- 5503513
- Journal Information:
- Science; (United States), Journal Name: Science; (United States) Vol. 204; ISSN SCIEA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL LOCALIZATION
BLOOD-PLASMA CLEARANCE
CLEARANCE
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
INFORMATION
INJECTION
INTAKE
INTESTINAL ABSORPTION
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAN
METABOLISM
MINUTES LIVING RADIOISOTOPES
NITRATES
NITROGEN 13
NITROGEN COMPOUNDS
NITROGEN ISOTOPES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORAL ADMINISTRATION
OXYGEN COMPOUNDS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES