I-123 labeled radiotracers in cardiovascular nuclear medicine

Journal Article · Thu Mar 31 23:00:00 EST 1983 · IEEE Trans. Nucl. Sci.; (United States)

DOI:https://doi.org/10.1109/TNS.1983.4332648· OSTI ID:5606136

Kulkarni, P V

Radiohalogens (particularly /sup 18/F, /SUP 34m/ C1, /sup 77/Br, /sup 75/Br, /sup 123/I, and /sup 125/I and /sup 211/At) produced in a cyclotron are nuclides of choice for radiopharmaceuticals. It has long been recognized that I-123 is the most desirable radioisotope of iodine for in vivo applications. I-123 labeled substrates suitable for imaging the myocardium include receptor binding agents, muscarinic antagonists and analogs of fatty acids. Radioiodinated (I-123) fatty acid analogs have gained significant attention because of the possibility that these might give quantitative information regarding the regional myocardial metabolic activity by noninvasive scintigraphic methods. Incorporation of tellurium hetero into a carbon skeleton or beta methylation of a long chain phenyl fatty acid tends to prolong the retention of radioactivity in the myocardium of experimental animals. It is recognized that the radioiodine needs to be placed on a phenyl ring attached (in the ..omega..-position) to a long chain fatty acid for the in vivo stability of the C-I-bond. Among the methods of radioiodination of ..omega..-phenyl fatty acids, a method developed in our laboratory using an organo-thallium intermediate has been found to be simple, efficient, reproducible, and suitable for routine application.

• Research Organization: Dept. of Radiology, The Univ. of Texas Health Science Center, Dallas, TX 75235
• OSTI ID: 5606136
• Journal Information: IEEE Trans. Nucl. Sci.; (United States), Journal Name: IEEE Trans. Nucl. Sci.; (United States) Vol. 30:2; ISSN IETNA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCELERATORS
ALPHA DECAY RADIOISOTOPES
ASTATINE 211
ASTATINE ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BROMINE 75
BROMINE 77
BROMINE ISOTOPES
CARDIOVASCULAR DISEASES
CHLORINE 34
CHLORINE ISOTOPES
CYCLIC ACCELERATORS
CYCLOTRONS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FLUORINE 18
FLUORINE ISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 125
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
RADIOPHARMACEUTICALS
SECONDS LIVING RADIOISOTOPES
TRACER TECHNIQUES