Radioiodinated ether phospholipid analogs as potential tumor-specific imaging agents
Radioiodinated analogs of the naturally-occurring alkyl lysophospholipid (ALP) were designed and synthesized for evaluation as potential tumor-specific imaging agents. The five iodinated ALP analogs synthesized were rac-1-O-(12-(m-iodophenyl)dodecyl)glycero-3-phosphocholine, ET-12IP-OH; rac-1-O-(12-(m-iodophenyl)dodecyl)-2-O-methylglycero-3-phosphocholine, ET-12IP-OMe; rac-1-O-(12-(m-iodophenyl)dodecyl)propane-1,3-diol-3-phosphocholine, ET-12IP-H; rac-1-O-hexadecyl-2-O-(m-iodobenzoyl)-glycero-3-phosphocholine, ET-16-IBz and rac-1-O-hexadecyl-2-O-(m-iodobenzyl)-glycero-3-phosphocholine, ET-16-IBn. Four analogs, ET-12IP-OMe, ET-12IP-H, ET-16-IBz and ET-16-IBn were radiolabeled with iodine-125 in moderate yields via an isotope exchange procedure. ({sup 125}I)ET-12IP-OMe, ({sup 125}I)ET-12IP-H and ({sup 125}I)ET-16-IBz were evaluated in tissue distribution (TD) studies involving both normal and tumor-bearing rats. The tumor chosen for this study was the Walker 256 sarcoma which was implanted in the thigh. Based upon the TD results and the tumor to nontumor ratios, ({sup 125}I)-ET-12IP-OMe was selected for scintigraphic studies with rats bearing the Walker 256 sarcoma. Twenty-four hours following administration of the radiolabeled ALP analog, external imaging with a gamma-camera clearly delineated the tumor.
- Research Organization:
- Michigan Univ., Ann Arbor, MI (USA)
- OSTI ID:
- 5605966
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
RADIOPHARMACEUTICALS
EVALUATION
SARCOMAS
DIAGNOSIS
EXPERIMENTAL NEOPLASMS
GAMMA CAMERAS
IODINE 125
RATS
SCINTISCANNING
TISSUE DISTRIBUTION
ANIMALS
BETA DECAY RADIOISOTOPES
CAMERAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics