Potential tumor or organ-imaging agents. 30. Radioiodinated phospholipid ethers

Journal Article · Fri Sep 01 00:00:00 EDT 1989 · Journal of Medicinal Chemistry; (USA)

DOI:https://doi.org/10.1021/jm00129a020· OSTI ID:5470678

Meyer, K L; Schwendner, S W; Counsell, R E ^[1]

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1. Univ. of Michigan, Ann Arbor (USA)

A radioiodinated analogue of a naturally occurring alkyl lysophospholipid (ALP) was synthesized for evaluation as a potential tumor-localizing imaging agent. rac-1-(12-(m-Iodophenyl)dodecyl)-2-methylglycero-3-phosphocholine (ET-12IP-OMe, 14) was radiolabeled with iodine-125 via an isotope-exchange procedure. Tissue distribution studies with ({sup 125}I)ET-12IP-OMe in tumor-bearing rats revealed an immediate tumor uptake of radioactivity. Although radioactivity was also present in nontarget tissues at this time, clearance of tracer from the tumor was much slower and thus provided a suitable tumor to nontarget tissue ratio at 24 h. As a result of this selective accumulation, it was possible to clearly delineate the tumor with gamma-camera scintigraphy.

• OSTI ID: 5470678
• Journal Information: Journal of Medicinal Chemistry; (USA), Vol. 32:9; ISSN 0022-2623
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
EXPERIMENTAL NEOPLASMS
DIAGNOSIS
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
ETHERS
IODINE 125
ISOTOPIC EXCHANGE
METABOLISM
PHOSPHOLIPIDS
RATS
SCINTISCANNING
TISSUE DISTRIBUTION
ANIMALS
BETA DECAY RADIOISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIPIDS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
SYNTHESIS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics