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Post-irradiation regression of choroidal melanomas as a risk factor for death from metastatic disease

Journal Article · · Ophthalmology (Rochester, Minn.); (United States)
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To determine the prognostic value of the regression rate of choroidal melanomas after cobalt-60 plaque radiotherapy, the authors performed a multivariate analysis on 159 patients treated with a cobalt plaque during the interval from 1976 through 1980. Thirty-three of the 159 patients had died as of the survey date; 29 of metastatic melanoma and 4 of other causes. Multivariate Cox proportional hazards modeling identified a two-term regression incorporating maximal basal tumor diameter at treatment and tumor thickness at 12 months posttreatment as the best model (P less than 0.005 for both parameters) for predicting length of tumor-free survival. These results are consistent with the hypothesis that rapid regression of a choroidal melanoma after cobalt-60 plaque radiotherapy is an unfavorable prognostic sign for prolonged metastasis-free survival.

Research Organization:
Wills Eye Hospital, Philadelphia, PA
OSTI ID:
5604619
Journal Information:
Ophthalmology (Rochester, Minn.); (United States), Journal Name: Ophthalmology (Rochester, Minn.); (United States) Vol. 94:9; ISSN OPHTD
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
COBALT 60
COBALT ISOTOPES
DISEASES
EYES
FACE
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATHEMATICS
MEDICINE
MELANOMAS
METASTASES
MINUTES LIVING RADIOISOTOPES
MULTIVARIATE ANALYSIS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATIENTS
POST-IRRADIATION EXAMINATION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
REGRESSION ANALYSIS
RISK ASSESSMENT
SENSE ORGANS
STATISTICS
SURVIVAL CURVES
THERAPY
YEARS LIVING RADIOISOTOPES